CryoEM structure of HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab and 2M2 Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fja
Q-score: 0.531
To Be Published
- Melanoma-associated antigen 4 peptide (Complex)
- Regn6972 fab light chain, regn6972 fab heavy chain (Complex from Homo sapiens)
- Mhc class i antigen, beta-2-microglobulin (Complex from Homo sapiens)
- Melanoma-associated antigen 4 peptide (1 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Regn6972 fab light chain (23 kDa, Protein from Homo sapiens)
- Hla-a2 magea4 (230-239) in complex with regn6972 fab and 2m2 fab (Complex)
- Regn6972 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
CryoEM structure of HLA-A2 MAGEA4 (286-294) in complex with H2aM31345N Fab and 2M2 Fab
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8fjb
Q-score: 0.574
To Be Published
- Melanoma-associated antigen 4 peptide (Complex)
- Mhc class i antigen, beta-2-microglobulin (Complex from Homo sapiens)
- Melanoma-associated antigen 4 peptide (1 kDa, Protein from Homo sapiens)
- H2am31345n fab heavy chain, h2am31345n fab light chain (Complex from Homo sapiens)
- H2am31345n fab heavy chain (23 kDa, Protein from Homo sapiens)
- Hla-a2 magea4 (286-294) complex with h2am31345n fab and 2m2 fab (Complex)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- H2am31345n fab light chain (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7stf
Q-score: 0.393
Wright KM, DiNapoli SR, Miller MS, Aitana Azurmendi P, Zhao X, Yu Z, Chakrabarti M, Shi W, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Pearlman AH, Paul S, Konig MF, Pardoll DM, Bettegowda C, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB
Nat Commun (2023) 14 pp. 5063-5063 [ Pubmed: 37604828 DOI: doi:10.1038/s41467-023-40821-w ]
- Igg, fab light chain v2 (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Ternary complex of antibody-fragment v2 with kras g12v/hla-a*03:01 (Complex)
- Igg, fab heavy chain v2 (23 kDa, Protein from Homo sapiens)
- Kras g12v (7-16) (885 Da, Protein from synthetic construct)
- Hla class i histocompatibility antigen, a alpha chain (32 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 in complex with HLA-A2 MAGEA4 (230-239)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8es8
Q-score: 0.537
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ DOI: doi:10.1038/s41467-023-37532-7 Pubmed: 37100770 ]
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex bound to hla-a2 magea4 (230-239) with anti-beta-2-microglobulin fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
CryoEM structure of PN45428 TCR-CD3 in complex with HLA-A2 MAGEA4
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8es9
Q-score: 0.475
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ DOI: doi:10.1038/s41467-023-37532-7 Pubmed: 37100770 ]
- Pn45428 tcr-cd3 complex bound to hla-a2 magea4 (230-239) in the presence of 2m2 fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- Pn45428 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45428 tcr beta chain (35 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
CryoEM structure of HLA-A2 bound to MAGEA4 (230-239) peptide
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8esa
Q-score: 0.527
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ DOI: doi:10.1038/s41467-023-37532-7 Pubmed: 37100770 ]
CryoEM structure of HLA-A2 bound to MAGEA8 (232-241) peptide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8esb
Q-score: 0.551
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ DOI: doi:10.1038/s41467-023-37532-7 Pubmed: 37100770 ]
beta-2-microglobulin DeltaN6 amyloid fibril form 2PFa
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a7o
Q-score: 0.579
Wilkinson M, Gallardo RU, Martinez RM, Guthertz N, So M, Aubrey LD, Radford SE, Ranson NA
Nat Commun (2023) 14 pp. 1190-1190 [ DOI: doi:10.1038/s41467-023-36791-8 Pubmed: 36864041 ]
beta-2-microglobulin DeltaN6 amyloid fibril form 2PFb
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a7p
Q-score: 0.462
Wilkinson M, Gallardo RU, Martinez RM, Guthertz N, So M, Aubrey LD, Radford SE, Ranson NA
Nat Commun (2023) 14 pp. 1190-1190 [ DOI: doi:10.1038/s41467-023-36791-8 Pubmed: 36864041 ]
beta-2-microglobulin V27M amyloid fibril form 4PF
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a7q
Q-score: 0.521
Wilkinson M, Gallardo RU, Martinez RM, Guthertz N, So M, Aubrey LD, Radford SE, Ranson NA
Nat Commun (2023) 14 pp. 1190-1190 [ DOI: doi:10.1038/s41467-023-36791-8 Pubmed: 36864041 ]